Dahn M S, Lange M P, McCurdy B, Mahaffey S
Department of Surgery, Wayne State University, Detroit, Michigan 48201, USA.
J Surg Res. 1995 Aug;59(2):287-91. doi: 10.1006/jsre.1995.1166.
Significant alterations of liver function have been identified in experimental sepsis including changes in protein and glucose production. The specific changes which are evident in vivo appear to depend upon the specific experimental model and probably represent the relative contribution of hepatocellular function and extrahepatic influences as well as the time course of the septic process. Relatively few studies have focused on function of the whole organ. In an effort to study intrinsic hepatic function during chronic sepsis, control and septic animals (intraabdominal abscess) were studied using the isolated perfused liver model. Basal hepatic oxygen utilization was mildly elevated compared to that in control livers and the oxygen consumption response to a metabolic load was found to be essentially identical to that in control and septic livers. Glucose and albumin production were not substantially different in these two groups. These findings suggest that alterations in liver function following the induction of sepsis may result from extra hepatic factors, since intrinsic liver function appears to be normal.
在实验性脓毒症中已发现肝功能有显著改变，包括蛋白质和葡萄糖生成的变化。体内明显的具体变化似乎取决于特定的实验模型，可能代表肝细胞功能和肝外影响的相对作用以及脓毒症过程的时间进程。相对较少的研究关注整个器官的功能。为了研究慢性脓毒症期间肝脏的内在功能，使用离体灌注肝脏模型对对照动物和脓毒症动物（腹腔内脓肿）进行了研究。与对照肝脏相比，基础肝氧利用率轻度升高，并且发现对代谢负荷的氧消耗反应与对照肝脏和脓毒症肝脏基本相同。这两组的葡萄糖和白蛋白生成没有实质性差异。这些发现表明，脓毒症诱导后肝功能的改变可能是由肝外因素引起的，因为肝脏的内在功能似乎是正常的。
