Groenen G, Saha N G, Rashid M A, Hamid M A, Pattyn S R
Damien Foundation, Bangladesh.
Lepr Rev. 1995 Jun;66(2):126-33. doi: 10.5935/0305-7518.19950014.
In 2 non-governmental organization projects in Bangladesh 244 new leprosy patients were classified in the field according to clinical criteria. Skin smears were taken at 4 standardized sites and at the most active peripheral lesion, where a biopsy was also taken. Comparison of the clinical field classification with the results of the skin smears and biopsies gives a sensitivity of 92.1% for the clinical criteria, but a specificity of only 41.3%. The skin-smear results, on the other hand, have a sensitivity of 88.4% and a specificity of 98.1%. Thus, skin smears may contribute considerably to the operational classification of leprosy patients under field conditions. Quality control of the peripheral laboratory is essential. Appropriate site selection for the smear taking will also contribute to increased performance. Analysis of the skin-smear results suggests that the policy of taking smears at standardized sites should be abandoned in favour of the earlobes and active peripheral lesions.
在孟加拉国的2个非政府组织项目中，根据临床标准在现场对244名新麻风病患者进行了分类。在4个标准化部位以及最活跃的外周皮损处采集皮肤涂片，同时在最活跃的外周皮损处进行活检。将临床现场分类结果与皮肤涂片和活检结果进行比较，结果显示临床标准的敏感性为92.1%，但特异性仅为41.3%。另一方面，皮肤涂片结果的敏感性为88.4%，特异性为98.1%。因此，皮肤涂片在外勤条件下对麻风病患者的操作分类可能有很大贡献。外周实验室的质量控制至关重要。涂片采集的合适部位选择也将有助于提高检测效果。对皮肤涂片结果的分析表明，应放弃在标准化部位采集涂片的政策，转而选择耳垂和活跃的外周皮损处。
