Marín O, González A, Smeets W J
Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense, Madrid, Spain.
Neurosci Lett. 1995 May 12;190(3):183-6. doi: 10.1016/0304-3940(95)11535-5.
The aim of the present study was to determine whether a dopaminergic mesolimbic pathway, as found in the brain of amniotes, also exists in anuran amphibians. For that purpose, application of retrograde tracers in the nucleus accumbens of Rana perezi was combined with tyrosine hydroxylase immunohistochemistry. Double labeled cells were found in the dorsomedial part of the posterior tubercle and, more frequently, in the midbrain tegmentum. It may be concluded, therefore, that a dopaminergic mesolimbic pathway does exist in amphibians. Nevertheless, the organization of the ventral (mesolimbic) and dorsal parts of the mesostriatal connections seems to vary from a caudal-to-rostral arrangement in amphibians to a medial-to-lateral arrangement in amniotes.
本研究的目的是确定在羊膜动物大脑中发现的多巴胺能中脑边缘通路是否也存在于无尾两栖动物中。为此，将逆行示踪剂应用于泽陆蛙伏隔核，并结合酪氨酸羟化酶免疫组织化学方法。在脑后部结节的背内侧部分发现了双标记细胞，且在中脑被盖中更为常见。因此，可以得出结论，两栖动物中确实存在多巴胺能中脑边缘通路。然而，中脑纹状体连接的腹侧（中脑边缘）和背侧部分的组织方式似乎有所不同，在两栖动物中是从尾侧到吻侧的排列，而在羊膜动物中是从内侧到外侧的排列。
