Barker D J, Gluckman P D, Robinson J S
MRC Environmental Epidemiology Unit, Southampton, UK.
Placenta. 1995 Apr;16(3):317-20. doi: 10.1016/0143-4004(95)90118-3.
The epidemiological observations that prenatal and perinatal events lead to adult disease are now well supported by animal data. The events in the periconceptual period, in early and late pregnancy and in infancy can effect programming of cardiovascular, endocrine and metabolic regulatory systems. However, the mechanisms underlying these pathological changes remain to be elucidated. Until this is addressed in experimental animals, clinical trials in human pregnancy are premature.
产前和围产期事件会导致成人疾病的流行病学观察结果，现在已得到动物数据的充分支持。受孕前后、妊娠早期和晚期以及婴儿期的事件可影响心血管、内分泌和代谢调节系统的编程。然而，这些病理变化背后的机制仍有待阐明。在实验动物中解决这个问题之前，针对人类妊娠的临床试验还为时过早。
