Langley-Evans S C, Gardner D S, Welham S J
Institute of Human Nutrition, University of Southampton, United Kingdom.
Nutrition. 1998 Jan;14(1):39-47. doi: 10.1016/s0899-9007(97)00391-2.
The origins of cardiovascular disease are related to genetic factors, postnatal environmental and behavioral influences, and also the environment experienced in utero. Patterns of disproportionate fetal growth consistent with maternal undernutrition appear to be predictive of later hypertension and coronary heart disease. These findings from epidemiologic studies are strongly supported by animal studies. Experimental models are suggestive of a role for glucocorticoid hormones in the intrauterine programming of cardiovascular function. New understanding of the relationships between maternal diet and the development and maturation of fetal tissues may enable prevention of cardiovascular disease by intervention in early life.
心血管疾病的起源与遗传因素、出生后的环境和行为影响以及子宫内经历的环境有关。与母亲营养不良相关的胎儿生长不均衡模式似乎可预测日后的高血压和冠心病。流行病学研究的这些发现得到了动物研究的有力支持。实验模型表明糖皮质激素在心血管功能的子宫内编程中起作用。对母亲饮食与胎儿组织发育和成熟之间关系的新认识可能有助于通过早期干预预防心血管疾病。
