101名健康日本人凝血因子VII基因的遗传多态性（Arg353→Gln）及因子VII水平（凝血活性、抗原及与组织因子的结合能力）

Genetic polymorphism (Arg353-->Gln) in coagulation factor VII gene and factor VII levels (coagulant activity, antigen and binding ability to tissue factor) in 101 healthy Japanese.

作者信息

Takamiya O

机构信息

Department of Medical Technology, School of Allied Medical Sciences, Shinshu University, Japan.

出版信息

Scand J Clin Lab Invest. 1995 May;55(3):211-5. doi: 10.3109/00365519509089615.

DOI:10.3109/00365519509089615

PMID:7638554

Abstract

We studied the frequency of the Msp I genotype (Gln353) for factor VII in 101 young healthy Japanese individuals, and the levels of factor VII-related procoagulant activity (FVII:c), antigen (FVII:ag) and binding ability to tissue factor (FVII-TF binding). The frequency of the allele coding for the factor VII Gln353 was 0.05 among this group. Individuals with genotype M1M1 had an FVII:c of 103.52 +/- 17.85% (mean +/- SD), FVII:ag of 102.50 +/- 18.42% (mean +/- SD) and FVII-TF binding of 101.03 +/- 22.22% (mean +/- SD). Triglyceride levels of subjects with the M1M1 genotype were 84.34 +/- 44.97 mg dl-1 (mean +/- SD). FVII:c (50%), FVII:ag (45%) and FVII-TF binding (36%) from an individual with the M2M2 type was the lowest, with a triglyceride value of 39 mg dl-1. On the other hand, individuals with the genotype M1M2 had an FVII:c of 75.57 +/- 9.61% (mean +/- SD), FVII:ag of 72.43 +/- 8.54% (mean +/- SD) and FVII-TF binding of 68.14 +/- 14.91% (mean +/- SD). FVII:c, FVII:ag and FVII-TF binding in individuals with the M1M2 and M2M2 genotypes were significantly lower than those in individuals with the M1M1 genotype.

摘要

我们研究了101名年轻健康的日本个体中凝血因子VII的Msp I基因型（Gln353）的频率，以及凝血因子VII相关的促凝血活性（FVII:c）、抗原（FVII:ag）水平和与组织因子的结合能力（FVII-TF结合）。在该组中，编码凝血因子VII Gln353的等位基因频率为0.05。基因型为M1M1的个体，其FVII:c为103.52±17.85%（平均值±标准差），FVII:ag为102.50±18.42%（平均值±标准差），FVII-TF结合为101.03±22.22%（平均值±标准差）。M1M1基因型受试者的甘油三酯水平为84.34±44.97mg/dl（平均值±标准差）。M2M2型个体的FVII:c（50%）、FVII:ag（45%）和FVII-TF结合（36%）最低，甘油三酯值为39mg/dl。另一方面，基因型为M1M2的个体，其FVII:c为75.57±9.61%（平均值±标准差），FVII:ag为72.43±8.54%（平均值±标准差），FVII-TF结合为68.14±14.91%（平均值±标准差）。M1M2和M2M2基因型个体的FVII:c、FVII:ag和FVII-TF结合显著低于M1M1基因型个体。