Fu Y T, He F S, Zhang S L, Zhang J S
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
Toxicon. 1995 Mar;33(3):327-31. doi: 10.1016/0041-0101(94)00173-6.
Using an electron spin resonance technique, free radical signals were observed to be increased in liver of rats 15, 30 and 45 min after orally dosing with 80 mg/kg 3-nitropropionic acid (3-NPA). Concentrations of 3-NPA from 595 to 2380 mg/litre enhanced the formation of adrenochrome from adrenaline in mitochondria and microsome suspensions of liver and brain. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) as well as the content of malonidialdehyde (MDA) were significantly increased in liver of rats dosed with 80 mg/kg 3-NPA. There was also a cerebral increase of activity of SOD and content of MDA. These results suggest that 3-NPA is able to produce lipid peroxidation both in vivo and in vitro.
采用电子自旋共振技术，观察到给大鼠口服80mg/kg 3-硝基丙酸（3-NPA）后15、30和45分钟，其肝脏中的自由基信号增强。浓度为595至2380mg/升的3-NPA可增强肝脏和脑线粒体及微粒体悬浮液中肾上腺素生成肾上腺色素的过程。给80mg/kg 3-NPA的大鼠肝脏中超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-PX）的活性以及丙二醛（MDA）的含量显著增加。大脑中SOD的活性和MDA的含量也有所增加。这些结果表明，3-NPA在体内和体外均能产生脂质过氧化作用。
