Doye V, Hurt E C
EMBL, Heidelberg, Germany.
Trends Genet. 1995 Jun;11(6):235-41. doi: 10.1016/s0168-9525(00)89057-5.
The major features of nucleocytoplasmic transport through nuclear pore complexes are conserved from yeast to humans. This transport machinery, which includes the 125 MDa nuclear pore complex structure, has been molecularly dissected in the yeast Saccharomyces cerevisiae by genetic approaches. Here, we summarize the genetic analyses used to elucidate structure-function relationships within this large supramolecular assembly.
从酵母到人类，通过核孔复合体进行的核质运输的主要特征是保守的。这种运输机制包括125 MDa的核孔复合体结构，已通过遗传方法在酿酒酵母中进行了分子剖析。在这里，我们总结了用于阐明这个大型超分子组装体内结构-功能关系的遗传分析。
