Sharma R P, Faull K, Javaid J I, Davis J M
Department of Psychiatry, University of Illinois at Chicago, USA.
Acta Psychiatr Scand. 1995 May;91(5):293-8. doi: 10.1111/j.1600-0447.1995.tb09785.x.
Cerebrospinal fluid levels of phenylacetic acid (CSF PAA) were obtained from normal controls and from drug-free psychiatric inpatients (schizophrenia, major depression, mania, and schizoaffective disorder). Post-treatment CSF PAA levels were obtained from 16 patients after 4 weeks of neuroleptic treatment. Phenylacetic acid levels were higher in women and were significantly correlated with age. There were no differences in CSF PAA levels between the various diagnostic groups and no difference between the paranoid and the nonparanoid subtypes of schizophrenia. CSF PAA was significantly correlated with several measures of psychopathology, especially the Brief Psychiatric Rating Scale hostility/suspiciousness factor. Neuroleptic treatment did not result in significant PAA changes. These findings are discussed in light of the amphetamine-like role ascribed to phenylethylamine, the precursor of PAA.
从正常对照组以及未服用药物的精神科住院患者（精神分裂症、重度抑郁症、躁狂症和分裂情感性障碍患者）中获取脑脊液苯乙酸（CSF PAA）水平。在16例患者接受4周抗精神病药物治疗后获取治疗后脑脊液苯乙酸水平。女性的苯乙酸水平较高，且与年龄显著相关。不同诊断组之间的脑脊液苯乙酸水平无差异，精神分裂症的偏执型和非偏执型亚型之间也无差异。脑脊液苯乙酸与多种精神病理学指标显著相关，尤其是简明精神病评定量表的敌意/怀疑因子。抗精神病药物治疗并未导致苯乙酸水平发生显著变化。根据苯乙酸前体苯乙胺被赋予的类似苯丙胺的作用对这些发现进行了讨论。
