Burnstein Y, Klapper D, Hersh P S
Cornea Consultation Service, Montefiore Medical Center, Bronx, NY, USA.
Arch Ophthalmol. 1995 Aug;113(8):1056-9. doi: 10.1001/archopht.1995.01100080108037.
To assess corneal weakening after photorefractive keratectomy.
Photorefractive keratectomy was performed in 16 human eye-bank eyes by means of a 193-nm excimer laser (range, 6 to 54 diopters [D]). Porcine eyes underwent either photorefractive keratectomy procedures (range, 30 to 93 D) with a 5-mm beam diameter or deep 5-mm plano disc ablations. Intraocular pressure was increased gradually with the use of nitrogen gas until the globe ruptured.
Human eyes with less than 42 D of correction ruptured at the limbus or behind the insertions of the extraocular muscles. Two eyes showed initial leakage at the 42-D ablation site. Ablations greater than 46 D entered the anterior chamber during treatment. One porcine eye ruptured at the ablation site after a 42-D treatment. Other eyes ruptured at the equator with treatments up to 78 D.
Excimer laser photorefractive keratectomy does not weaken the cornea after degrees of ablation commonly used in the clinical setting.
评估准分子激光原位角膜磨镶术后角膜的弱化情况。
使用193纳米准分子激光（范围为6至54屈光度[D]）对16只人眼库眼球进行准分子激光原位角膜磨镶术。猪眼接受5毫米光束直径的准分子激光原位角膜磨镶术（范围为30至93 D）或5毫米深度的平面盘状消融术。使用氮气逐渐增加眼内压直至眼球破裂。
矫正度数小于42 D的人眼在角膜缘或眼外肌附着点后方破裂。两只眼睛在42 D消融部位出现初始渗漏。大于46 D的消融在治疗期间进入前房。一只猪眼在42 D治疗后在消融部位破裂。其他眼睛在赤道处破裂，治疗度数高达78 D。
在临床常用的消融度数后，准分子激光原位角膜磨镶术不会削弱角膜。
