Snibson G R, Carson C A, Aldred G F, Taylor H R
Department of Ophthalmology, University of Melbourne, Australia.
Arch Ophthalmol. 1995 Aug;113(8):994-1000. doi: 10.1001/archopht.1995.01100080044028.
To evaluate prospectively the efficacy and safety of excimer laser photorefractive keratectomy in the treatment of myopia and myopic astigmatism.
Up to 15 diopters (D) of myopia with or without astigmatism of less than 6 D was treated with an excimer laser (VISX Twenty/Twenty). One hundred fifty procedures have been followed up for more than 12 months.
Postoperative refractions were generally stable after 3 months without significant early overcorrection. Of those eyes treated with spherical equivalents of 5 D or less, 96% were within 1 D of the targeted refraction after photorefractive keratectomy and 88% had uncorrected visual acuities of 20/40 or better. At 12 months, 77% of all 150 eyes treated achieved an uncorrected visual acuity of 20/40 or better and 81% were within 1 D of the intended correction. Nine eyes (6%) lost 2 or more lines of best corrected visual acuity and 14 (9%) gained 2 or more lines. Adverse reactions were reported in 12 patients (8%) during the postoperative period.
Photorefractive keratectomy is capable of correcting low and moderate myopic errors with a relatively high degree of accuracy and safety. The predictability and stability of the postoperative refraction during the first 12 months seem to be good.
前瞻性评估准分子激光屈光性角膜切削术治疗近视及近视散光的有效性和安全性。
使用准分子激光（VISX Twenty/Twenty）治疗近视度数高达15屈光度（D），伴有或不伴有散光度数小于6 D的患者。150例手术患者已随访超过12个月。
术后3个月屈光状态一般稳定，无明显早期过矫。在等效球镜度数为5 D或更低的治疗眼中，96%在屈光性角膜切削术后的屈光度数在目标度数的±1 D范围内，88%的患者裸眼视力达到20/40或更好。在12个月时，所有150只接受治疗的眼中，77%的患者裸眼视力达到20/40或更好，81%的患者屈光度数在预期矫正度数的±1 D范围内。9只眼（6%）最佳矫正视力下降2行或更多，14只眼（9%）最佳矫正视力提高2行或更多。术后有12例患者（8%）报告了不良反应。
屈光性角膜切削术能够以较高的准确性和安全性矫正中低度近视性屈光不正。术后前12个月屈光的可预测性和稳定性似乎良好。
