Obata T, Ikehira H, Shishido F, Fukuda N, Ueshima Y, Koga M, Kato H, Kimura F, Tateno Y
Division of Clinical Research, National Institute of Radiological Sciences, Chiba, Japan.
Acta Radiol. 1995 Sep;36(5):552-5.
In vivo deuterium MR imaging (2H MR) was investigated in rats after intraperitoneal administration of deuterated saline, and a dynamic study of the water movement in rat eyes was performed. Deuterium MR imaging was carried out by means of a gradient-echo (GRE) and a spin-echo (SE) pulse sequence. The rat eye was imaged in 2H MR more selectively by SE than by GRE, but a lower signal-to-noise ratio was obtained in 2H MR imaging using the SE sequence. The MR signal intensity of the rat eye was followed by a 3-compartment model, which enabled determination of the flow rate constant of the water in the eye (0.359/min). Deuterium MR imaging is useful to visualize the dynamic change of water in rat eyes using 2H MR at the same magnetic field (2 T) that can also be used for conventional MR imaging in humans.
在大鼠腹腔注射氘化盐水后，对其进行了体内氘磁共振成像（2H MR）研究，并对大鼠眼睛中的水运动进行了动态研究。氘磁共振成像通过梯度回波（GRE）和自旋回波（SE）脉冲序列进行。在2H MR中，大鼠眼睛通过SE比通过GRE成像更具选择性，但使用SE序列进行2H MR成像时获得的信噪比更低。采用三室模型跟踪大鼠眼睛的磁共振信号强度，该模型能够确定眼中水的流速常数（0.359/分钟）。氘磁共振成像有助于在与人体常规磁共振成像相同的磁场（2T）下，利用2H MR可视化大鼠眼睛中水的动态变化。
