氘代谢成像——一种光谱工具的重新发现

Polvoy Ilona, Qin Hecong, Flavell Robert R, Gordon Jeremy, Viswanath Pavithra, Sriram Renuka, Ohliger Michael A, Wilson David M

Department of Radiology and Biomedical Imaging, University of California, 185 Berry St., San Francisco, CA 94158, USA.

Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA.

Metabolites. 2021 Aug 25;11(9):570. doi: 10.3390/metabo11090570.

The growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium (H) Metabolic Imaging (DMI), a robust method based on administration of a substrate (glucose, acetate, fumarate, etc.) labeled with the stable isotope of hydrogen and the observation of its metabolic fate in three-dimensions. This technique allows the investigation of multiple metabolic processes in both healthy and diseased states. Despite its low natural abundance, the short relaxation time of deuterium allows for rapid radiofrequency (RF) pulses without saturation and efficient image acquisition. In this review, we provide a comprehensive picture of the evolution of DMI over the course of recent decades, with a special focus on its potential clinical applications.

对代谢特异性成像技术日益增长的需求重新点燃了人们对氘（H）代谢成像（DMI）的兴趣，这是一种基于给予用氢的稳定同位素标记的底物（葡萄糖、乙酸盐、富马酸盐等）并三维观察其代谢命运的强大方法。该技术能够研究健康和疾病状态下的多种代谢过程。尽管氘的天然丰度较低，但其短弛豫时间允许进行无饱和的快速射频（RF）脉冲和高效的图像采集。在本综述中，我们全面介绍了近几十年来DMI的发展历程，特别关注其潜在的临床应用。