Gabra H, Taylor L, Cohen B B, Lessels A, Eccles D M, Leonard R C, Smyth J F, Steel C M
ICRF Medical Oncology Unit, Western General Hospital, Edinburgh, UK.
Br J Cancer. 1995 Aug;72(2):367-75. doi: 10.1038/bjc.1995.340.
Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epithelial ovarian cancers (EOCs). Forty EOCs (85%) showed allele imbalance at one or more loci, and in 39 of these (83%) the data suggested subchromosomal deletions: eight of 11p only; six of 11q only; and 25 of both 11p and 11q. Three consensus regions of deletion were indicated at 11p15.5-p15.3, 11q12-q22 and 11q23.3-q24.1. Allele imbalance at the 11q subtelomeric region (D11S912) correlated significantly with adverse survival, while imbalance at 11q14.3 and retention of heterozygosity at 11q22 (close to the site of the progesterone receptor gene) were associated with favourable clinicopathological features. The findings allow development of a preliminary model for the molecular evolution of epithelial ovarian cancer.
卵巢癌中11号染色体位点的等位基因失衡是常见现象，提示该染色体上存在参与卵巢癌发生的肿瘤抑制基因。使用10个高度多态性的（CA）重复微卫星来确定60例原发性卵巢肿瘤中的等位基因失衡情况，其中包括47例上皮性卵巢癌（EOC）。40例EOC（85%）在一个或多个位点显示等位基因失衡，其中39例（83%）的数据提示存在亚染色体缺失：仅11p有8例；仅11q有6例；11p和11q均有25例。在11p15.5 - p15.3、11q12 - q22和11q23.3 - q24.1处显示出三个缺失的共识区域。11q亚端粒区域（D11S912）的等位基因失衡与不良生存显著相关，而11q14.3处的失衡以及11q22（靠近孕激素受体基因位点）的杂合性保留与良好的临床病理特征相关。这些发现有助于建立上皮性卵巢癌分子进化的初步模型。
