Pinholt E M, Haanaes H R, Donath K, Bang G
Institute for Surgical Research, Rikshospitalet, Dental Faculty, University of Oslo, Norway.
Clin Oral Implants Res. 1994 Dec;5(4):213-9. doi: 10.1034/j.1600-0501.1994.050404.x.
The purpose of this investigation was to evaluate whether titanium endosseous implants would osseointegrate in dog alveolar ridges augmented by allogenic material. In 8 dogs en bloc resection, including 2 pre-molars, was performed bilaterally in the maxilla and the mandible. After a healing period of 6 weeks allogenic, demineralized and lyophilized dentin or bone was implanted subperiosteally. Titanium implants were installed 5.5 months later in some of the regions. Light and fluorescence microscopic evaluation revealed fibrous encapsulation of the implanted allogenic material, no osteoinduction and only minimal osteoconduction, few multinuclear giant cells and a sparse inflammatory reaction. The titanium implants healed mainly by fibrous encapsulation.
本研究的目的是评估钛骨内种植体是否能在同种异体材料增强的犬牙槽嵴中实现骨整合。对8只犬双侧上颌和下颌进行整块切除,包括2颗前磨牙。在6周的愈合期后,将同种异体、脱矿冻干牙本质或骨植入骨膜下。5.5个月后在部分区域植入钛种植体。光镜和荧光显微镜评估显示,植入的同种异体材料被纤维包裹,无骨诱导现象,仅有轻微的骨传导,多核巨细胞很少,炎症反应稀疏。钛种植体主要通过纤维包裹实现愈合。