Feuille Frank, Knapp Charles I, Brunsvold Michael A, Mellonig James T
US Navy Dental Corps, Naval Dental Center, San Diego, California, USA.
Int J Periodontics Restorative Dent. 2003 Feb;23(1):29-35.
The purpose of this study was to evaluate the use of mineralized freeze-dried bone allograft (FDBA) in conjunction with a titanium-reinforced expanded polytetrafluoroethylene (TR e-PTFE) barrier in the treatment of localized alveolar ridge deficiencies prior to endosseous dental implant placement. Twelve patients (aged 23 to 65 years) requiring tooth replacement with ridge augmentation were recruited to participate in this study. During ridge augmentation surgery, measurements were made prior to grafting with FDBA plus a TR e-PTFE barrier. Six months later, ridge measurements were repeated, and suitability for implant placement was assessed. At each implant site, a biopsy was taken from the grafted site. The implants were placed and allowed to osseointegrate for 13 weeks prior to phase-two surgery. Clinical data analyzed were horizontal ridge width changes and vertical ridge height changes. Histologic evaluation revealed the formation of new bone and residual particles in each graft site at the time of implant placement Ten patients completed the study. The mean alveolar ridge width increased by 3.2 +/- 1.0 mm (P < .0005). Histomorphometric analysis revealed a range of new bone from 42.9% to 70.5%, with a mean of 47.6%. Graft particles remaining ranged from 29.5% to 57.1%, with a mean of 52.4%. The clinical and histologic findings of this study demonstrate that sites grafted with FDBA in conjunction with an e-PTFE barrier can provide a predictable way to augment deficient alveolar ridges prior to implant placement.
本研究的目的是评估矿化冻干骨同种异体移植物（FDBA）联合钛增强型膨体聚四氟乙烯（TR e-PTFE）屏障在牙种植体植入前治疗局限性牙槽嵴缺损中的应用。招募了12例（年龄23至65岁）需要进行牙槽嵴增高以进行牙齿修复的患者参与本研究。在牙槽嵴增高手术期间，在植入FDBA加TR e-PTFE屏障之前进行测量。6个月后，重复进行牙槽嵴测量，并评估植入的适宜性。在每个种植部位，从移植部位取活检组织。植入种植体并使其骨整合13周后进行二期手术。分析的临床数据为水平牙槽嵴宽度变化和垂直牙槽嵴高度变化。组织学评估显示，在植入种植体时，每个移植部位均有新骨形成和残留颗粒。10例患者完成了研究。牙槽嵴平均宽度增加了3.2±1.0 mm（P <.0005）。组织形态计量学分析显示新骨范围为42.9%至70.5%，平均为47.6%。残留的移植颗粒范围为29.5%至57.1%，平均为52.4%。本研究的临床和组织学结果表明，用FDBA联合e-PTFE屏障移植的部位可为种植体植入前增高不足的牙槽嵴提供一种可预测的方法。
