Brissette W H, Baker D A, Stam E J, Umland J P, Griffiths R J
Department of Immunology and Infectious Diseases, Pfizer Inc., Groton, CT 06340, USA.
Cytokine. 1995 Apr;7(3):291-5. doi: 10.1006/cyto.1995.0035.
Subcutaneous administration of Granulocyte-macrophage-colony stimulating factor (GM-CSF) to mice enhanced LPS-induced cytokine production in the circulation (TNF, IL-6) and peritoneal cavity (IL-1 beta, IL-6). This effect was induced rapidly (within 1 h) and persisted for 4 h. Mice made leukopenic with cyclophosphamide retained the ability to respond to GM-CSF. In addition, TNF induced IL-6 production was also enhanced. These results demonstrate that GM-CSF has a pronounced priming effect on cytokine producing cells in vivo and raises the possibility that this cytokine may contribute to the pathogenesis of septic shock.
对小鼠皮下注射粒细胞-巨噬细胞集落刺激因子（GM-CSF）可增强脂多糖诱导的循环系统（肿瘤坏死因子、白细胞介素-6）和腹腔（白细胞介素-1β、白细胞介素-6）中的细胞因子产生。这种效应迅速诱导产生（1小时内）并持续4小时。用环磷酰胺使小鼠白细胞减少后，其仍保留对GM-CSF作出反应的能力。此外，肿瘤坏死因子诱导的白细胞介素-6产生也增强。这些结果表明，GM-CSF在体内对细胞因子产生细胞具有显著的启动作用，并增加了这种细胞因子可能促成脓毒性休克发病机制的可能性。
