Celener D, Ledesma de Paolo M I, González E, Bonfanti M, Rosembeck G, Bandi J C, Tiscornia O, Bustos Fernández L
Intituto de Gastroenterología Dr. Jorge Pérez Companc, Buenos Aires, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1994;44(1-2):11-6.
In this work we have demonstrated the influence of a short chain fatty acid (acetate) on the number of enterochromaffin (EC) cells containing serotonin (5HT), at two different pH (pH 6.9 absorptive stimuli, and pH 2.9 secretory stimuli), infused into the colon during one hour. The number of EC cells decrease significatively, specially in the cecum with a solution of low pH (2.9). The action of piprenzepine in preventing this reduction demonstrated that was partly mediated by a cholinergic receptor mechanism. On the other hand, a decrease on the release of 5HT to the lumen was a observed under the influence of pirenzepine. We conclude that the short chain fatty acid acetate, at a low pH induces the release of serotonin through a cholinergic mechanisms indicated by the inhibition observed with antimuscarinic drug.
在这项研究中，我们展示了短链脂肪酸（乙酸盐）对含5-羟色胺（5HT）的肠嗜铬（EC）细胞数量的影响，在两种不同的pH值（pH 6.9时为吸收性刺激，pH 2.9时为分泌性刺激）下，持续一小时注入结肠。EC细胞数量显著减少，特别是在低pH值（2.9）溶液作用下的盲肠中。哌仑西平阻止这种减少的作用表明，其部分是由胆碱能受体机制介导的。另一方面，在哌仑西平的影响下，观察到5HT向肠腔的释放减少。我们得出结论，在低pH值时，短链脂肪酸乙酸盐通过抗毒蕈碱药物观察到的抑制作用所表明的胆碱能机制诱导5-羟色胺的释放。
