Garmyn M, Ribaya-Mercado J D, Russel R M, Bhawan J, Gilchrest B A
USDA Human Nutrition Research Center on Aging, Tufts University, MA, USA.
Exp Dermatol. 1995 Apr;4(2):104-11. doi: 10.1111/j.1600-0625.1995.tb00231.x.
Beta-carotene, a quencher of excited species such as singlet oxygen and free radicals, has been reported to protect against cutaneous photodamage, including sunburn acutely and photocarcinogenesis chronically. The present double blind placebo-controlled study examines the effect of beta-carotene supplementation on the human sunburn response and specifically on the induction of sunburn cells at the time of peak reaction intensity (24 h) after a single solar simulated light exposure 3 times the individually determined minimal erythema dose (MED). Administered orally either as a single 120 mg dose to dietarily restricted subjects or for 23 d as a daily 90 mg supplement to subjects on standard diets, beta-carotene increased plasma and skin levels of beta-carotene compared to both pretreatment levels and placebo-treated controls, but provided no clinically or histologically detectable protection against a 3 MED sunburn reaction. Thus, these data suggest that oral beta-carotene supplementation is unlikely to modify the severity of cutaneous photodamage in normal individuals to a clinically meaningful degree.
β-胡萝卜素是单线态氧和自由基等激发态物质的猝灭剂，据报道它可预防皮肤光损伤，包括急性晒伤和慢性光致癌作用。本双盲安慰剂对照研究考察了补充β-胡萝卜素对人体晒伤反应的影响，特别是在单次模拟日光照射达到个体确定的最小红斑量（MED）的3倍后，在反应强度峰值（24小时）时对晒伤细胞诱导的影响。给予饮食受限的受试者单次口服120毫克剂量，或给予标准饮食的受试者每日口服90毫克补充剂，持续23天，与预处理水平和安慰剂对照相比，β-胡萝卜素提高了血浆和皮肤中β-胡萝卜素的水平，但对3倍MED晒伤反应未提供临床或组织学可检测到的保护作用。因此，这些数据表明，口服补充β-胡萝卜素不太可能将正常个体皮肤光损伤的严重程度改变到具有临床意义的程度。
