Chabriat H, Tehindrazanarivelo A, Vera P, Samson Y, Pappata S, Boullais N, Bousser M G
Service Hospitalier Frédéric Joliot, Orsay, France.
Cephalalgia. 1995 Apr;15(2):104-8; discussion 77. doi: 10.1046/j.1468-2982.1995.015002104.x.
Since the brain 5HT2 receptors might be implicated in migraine pathogenesis, we have used positron emission tomography and 18F-fluorosetoperone, a 5HT2 specific radioligand, to investigate in vivo the cortical 5HT2 receptors in migraine subjects. Nine migraineurs who had either migraine with and without aura (n = 5) or only migraine without aura (n = 4) were studied between attacks. Twelve unmedicated healthy subjects of similar mean age were used as controls. Brain radioactivity was measured after 18F-setoperone IV injection for 90 min. A decrease of the regional specific distribution volumes (SDV) of the ligand was observed both in migraineurs and in controls. The age adjusted group means of SDV did not differ between patients and controls for the whole and for the right or left frontal, temporal, parietal and occipital cortex. These results suggest that cortical 5HT2 receptors may be unaltered between attacks in migraine sufferers.
由于大脑5-羟色胺2（5HT2）受体可能与偏头痛发病机制有关，我们使用正电子发射断层扫描和5HT2特异性放射性配体18F-氟西托品，对偏头痛患者的皮质5HT2受体进行了体内研究。在发作间期对9名偏头痛患者进行了研究，其中5名有先兆偏头痛患者和无先兆偏头痛患者，4名仅有无先兆偏头痛患者。选取12名平均年龄相近的未用药健康受试者作为对照。静脉注射18F-西托品90分钟后测量脑放射性。在偏头痛患者和对照组中均观察到配体区域特异性分布体积（SDV）降低。对于整个大脑以及右侧或左侧额叶、颞叶、顶叶和枕叶皮质，患者和对照组经年龄调整后的SDV组均值无差异。这些结果表明，偏头痛患者发作间期皮质5HT2受体可能未发生改变。
