Trichard C, Paillère-Martinot M L, Attar-Levy D, Blin J, Feline A, Martinot J L
INSERM U334, S.H.F.J., DRM, DSV, CEA, Orsay, France.
Schizophr Res. 1998 May 4;31(1):13-7. doi: 10.1016/s0920-9964(98)00014-0.
To investigate putative abnormalities of cortical 5-HT2A receptor density in schizophrenia, we used positron emission tomography and [18F]setoperone, a high-affinity 5-HT2A receptor radioligand, in 14 neuroleptic-free or -naive schizophrenic patients and in 15 normal controls. No significant difference between the groups was observed in the whole or regional cortical binding potential of [18F]setoperone, indicating an absence of major 5-HT2A receptor cortical density abnormalities in schizophrenics.
为了研究精神分裂症患者皮质5-羟色胺2A（5-HT2A）受体密度的假定异常情况，我们对14名未使用过抗精神病药物或初次发病的精神分裂症患者以及15名正常对照者，使用正电子发射断层扫描术和[18F]司替戊醇（一种高亲和力的5-HT2A受体放射性配体）进行了研究。两组之间在[18F]司替戊醇的整体或区域皮质结合潜能方面未观察到显著差异，这表明精神分裂症患者不存在主要的5-HT2A受体皮质密度异常。
