Vangsness C T, Smith C F, Marshall G J, Sweeney J R, Johansen E
Department of Orthopaedic Surgery, University of Southern California School of Medicine, Los Angeles, USA.
Clin Orthop Relat Res. 1995 Jan(310):48-51.
A pulsed carbon dioxide laser made predetermined superficial and deep (subchondral) lesions through arthrotomies on the femoral condyles of adult New Zealand rabbits. Twenty rabbits, including controls, were divided into acute, 1-, 3-, 6-, and 12-month sacrifice groups. Early sacrifice groups showed some fibrous ingrowth from the deep lesions, but not the superficial lesions, and this was not seen in the 6- or 12-month groups. Cells below and adjacent to the laser lesions appeared viable when compared with controls. In each group studied, no histologic evidence of healing or fibrous covering in the superficial or deep laser lesions was found. No adverse clinical effects (synovitis, infection) were found in the laser groups, and the laser permitted excellent depth control during vaporization. However, the authors caution against irradiating articular cartilage.
一台脉冲二氧化碳激光通过对成年新西兰兔股骨髁进行关节切开术制造了预定的浅表和深部（软骨下）损伤。包括对照组在内的20只兔子被分为急性、1个月、3个月、6个月和12个月处死组。早期处死组显示深部损伤有一些纤维长入，但浅表损伤没有，而在6个月或12个月组中未见到这种情况。与对照组相比，激光损伤下方及相邻的细胞看起来是存活的。在每个研究组中，未发现浅表或深部激光损伤有愈合或纤维覆盖的组织学证据。激光组未发现不良临床效应（滑膜炎、感染），并且激光在汽化过程中能实现出色的深度控制。然而，作者告诫不要对关节软骨进行照射。
