Lau S S
Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin 78712, USA.
Drug Metab Rev. 1995;27(1-2):125-41. doi: 10.3109/03602539509029819.
It is clear that quinone-thioethers possess a variety of biological and toxicological activity [5]. The ubiquitous nature of quinones and the high concentrations of GSH within cells virtually guarantees that humans will be exposed to the potential adverse effects of the resulting quinone-thioethers. The generation of a biologically reactive intermediate is usually the initial and necessary step that eventually results in cell death, tissue necrosis, and/or tumor formation. The various mechanisms in which reactive intermediates interact with cellular constituents and trigger events that lead to cell death or cell transformation, are only now becoming unravelled. Knowledge of the disposition of quinone-thioethers will therefore be an important prerequisite to understanding their mechanism of action. Studies on the occurrence and biological and toxicological activity of quinone-thioethers therefore will be an important area for future research.
显然，醌硫醚具有多种生物学和毒理学活性[5]。醌的普遍存在以及细胞内高浓度的谷胱甘肽实际上保证了人类会接触到由此产生的醌硫醚的潜在不利影响。生成具有生物活性的中间体通常是最终导致细胞死亡、组织坏死和/或肿瘤形成的初始且必要步骤。反应性中间体与细胞成分相互作用并引发导致细胞死亡或细胞转化的事件的各种机制，直到现在才逐渐被揭示。因此，了解醌硫醚的处置情况将是理解其作用机制的重要前提。因此，关于醌硫醚的存在及其生物学和毒理学活性的研究将是未来研究的一个重要领域。
