• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts.

作者信息

Hinson J A, Pumford N R, Roberts D W

机构信息

Division of Toxiciology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.

出版信息

Drug Metab Rev. 1995;27(1-2):73-92. doi: 10.3109/03602539509029816.

DOI:10.3109/03602539509029816
PMID:7641586
Abstract
摘要

相似文献

1
Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts.对乙酰氨基酚毒性的机制:药物 - 蛋白质加合物的免疫化学检测
Drug Metab Rev. 1995;27(1-2):73-92. doi: 10.3109/03602539509029816.
2
Acetaminophen-induced hepatotoxicity. Analysis of total covalent binding vs. specific binding to cysteine.对乙酰氨基酚诱导的肝毒性。总共价结合与对半胱氨酸特异性结合的分析。
Drug Metab Dispos. 1996 Nov;24(11):1192-6.
3
Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice.
J Pharmacol Exp Ther. 1989 Jan;248(1):190-6.
4
A sensitive immunochemical assay for acetaminophen-protein adducts.
J Pharmacol Exp Ther. 1987 May;241(2):527-33.
5
Monitoring drug-protein interaction.监测药物-蛋白质相互作用。
Clin Chim Acta. 2006 Mar;365(1-2):9-29. doi: 10.1016/j.cca.2005.08.021. Epub 2005 Sep 30.
6
Pharmacokinetic considerations in toxicity testing.毒性试验中的药代动力学考量
Drug Metab Rev. 1982;13(6):983-1007. doi: 10.3109/03602538208991373.
7
Pharmacokinetic consequences and toxicologic implications of endogenous cosubstrate depletion.
Drug Metab Rev. 1982;13(6):1009-20. doi: 10.3109/03602538208991374.
8
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.不明原因急性肝衰竭患儿对乙酰氨基酚蛋白加合物的检测
Pediatrics. 2006 Sep;118(3):e676-81. doi: 10.1542/peds.2006-0069.
9
Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress.对乙酰氨基酚诱导肝毒性的机制:共价结合与氧化应激。
Chem Res Toxicol. 1996 Apr-May;9(3):580-5. doi: 10.1021/tx950153d.
10
Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.双氯芬酸在大鼠小肠中蛋白质加合物的免疫化学检测与鉴定:在过敏反应中的可能作用
Chem Res Toxicol. 1998 Mar;11(3):164-71. doi: 10.1021/tx970182j.

引用本文的文献

1
Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review).对乙酰氨基酚诱导的肝损伤的潜在机制与治疗(综述)
Mol Med Rep. 2025 Apr;31(4). doi: 10.3892/mmr.2025.13471. Epub 2025 Feb 28.
2
Therapeutic anti-inflammatory immune potentials of some seaweeds extracts on chemically induced liver injury in mice.某些海藻提取物对化学诱导的小鼠肝损伤的治疗性抗炎免疫潜力。
Sci Rep. 2025 Feb 5;15(1):4370. doi: 10.1038/s41598-025-87379-9.
3
Future directions in acute liver failure.急性肝衰竭的未来方向。
Hepatology. 2023 Oct 1;78(4):1266-1289. doi: 10.1097/HEP.0000000000000458. Epub 2023 May 16.
4
Echinacoside alleviates acetaminophen-induced liver injury by attenuating oxidative stress and inflammatory cytokines in mice.松果菊苷通过减轻氧化应激和炎症细胞因子缓解对乙酰氨基酚诱导的小鼠肝损伤。
J Appl Biomed. 2021 May;19(2):105-112. doi: 10.32725/jab.2021.011. Epub 2021 Apr 26.
5
The development and hepatotoxicity of acetaminophen: reviewing over a century of progress.对乙酰氨基酚的发展及其肝毒性:回顾一个多世纪的进展。
Drug Metab Rev. 2020 Nov;52(4):472-500. doi: 10.1080/03602532.2020.1832112. Epub 2020 Oct 14.
6
Acetaminophen Toxicity: A History of Serendipity and Unintended Consequences.对乙酰氨基酚毒性:意外发现与意外后果的历史。
Clin Liver Dis (Hoboken). 2020 Oct 7;16(Suppl 1):34-44. doi: 10.1002/cld.984. eCollection 2020 Oct.
7
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.基于证据选择用于人体药物性肝损伤机制整合预测的训练化合物。
Arch Toxicol. 2016 Dec;90(12):2979-3003. doi: 10.1007/s00204-016-1845-1. Epub 2016 Sep 22.
8
Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides.抗疟四氢异喹啉甲酰胺的先导化合物发现研究
J Med Chem. 2016 Sep 8;59(17):7950-62. doi: 10.1021/acs.jmedchem.6b00752. Epub 2016 Aug 25.
9
Apoptotic events induced by high glucose in human hepatoma HepG2 cells involve endoplasmic reticulum stress and MAPK's activation.高糖诱导人肝癌HepG2细胞发生的凋亡事件涉及内质网应激和丝裂原活化蛋白激酶(MAPK)的激活。
Mol Cell Biochem. 2015 Jan;399(1-2):113-22. doi: 10.1007/s11010-014-2238-5. Epub 2014 Oct 9.
10
The effects of hazardous chemical exposure on cardiovascular disease in chemical products manufacturing workers.化学制品制造业工人接触有害化学物质对心血管疾病的影响。
Toxicol Res. 2012 Dec;28(4):269-77. doi: 10.5487/TR.2012.28.4.269.