Glock J L, Brumsted J R
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington 05405, USA.
Fertil Steril. 1995 Sep;64(3):500-4.
To determine whether color flow pulsed Doppler analysis of corpus luteum blood flow in normal cycles differs from cycles with a luteal phase defect.
A prospective study of natural ovarian cycles.
The University of Vermont Reproductive Endocrinology and Infertility Service.
Ten women with regular menstrual cycles and at risk for luteal phase defect (LPD) four with unexplained infertility, two with recurrent abortion, and four with age > 35 years.
All women were examined by transvaginal color flow pulsed Doppler during the early follicular, late follicular, early luteal, midluteal, and late luteal phase of the menstrual cycle. Venous blood for P concentration was drawn on each day of Doppler exam. Urine testing for LH surge and endometrial biopsy during the late luteal phase were performed on each patient.
Lowest resistance index associated with the highest amplitude signal from intraovarian vessels of each ovary, dated endometrial biopsies, serum P.
Mean resistance indexes in LPD patients (n = 3) were significantly higher compared with normal women (n = 6) throughout the follicular and luteal phases. One patient remained anovulatory and was excluded from statistical analysis. Although systolic and diastolic velocities generally were observed to be lower in LPD patients compared with normal women, these differences were not statistically significant. High correlations were observed between P and resistance index within each luteal time point, achieving its highest value during the midluteal phase.
This initial study provides evidence that color flow pulsed Doppler analysis of blood flow impedance to the corpus luteum may aid in assessing luteal phase adequacy.
确定正常月经周期中黄体血流的彩色多普勒脉冲分析与黄体期缺陷周期是否存在差异。
对自然卵巢周期的前瞻性研究。
佛蒙特大学生殖内分泌与不孕不育科。
10名月经周期规律且有黄体期缺陷风险的女性(4名不明原因不孕、2名复发性流产、4名年龄>35岁)。
所有女性在月经周期的卵泡早期、卵泡晚期、黄体早期、黄体中期和黄体晚期接受经阴道彩色多普勒脉冲检查。在每次多普勒检查日采集静脉血检测P浓度。对每位患者在黄体晚期进行LH峰尿液检测和子宫内膜活检。
与每个卵巢卵巢内血管最高幅度信号相关的最低阻力指数、子宫内膜活检日期、血清P。
在整个卵泡期和黄体期,黄体期缺陷患者(n = 3)的平均阻力指数显著高于正常女性(n = 6)。1例患者持续无排卵,被排除在统计分析之外。虽然一般观察到黄体期缺陷患者的收缩期和舒张期速度低于正常女性,但这些差异无统计学意义。在每个黄体期时间点,P与阻力指数之间观察到高度相关性,在黄体中期达到最高值。
这项初步研究提供了证据,表明对黄体血流阻抗进行彩色多普勒脉冲分析可能有助于评估黄体期是否充足。