Critical review of the animal models of generalized epilepsies.

The state of the art for models of generalized seizures in animals is satisfactory, but improvable for what concerns primary generalized seizures of Petit-Mal type. Other models of secondary generalized seizures are available allowing acceptable ways of studying some mechanisms of epileptogenesis, and/or screening potentials new AEDs. For other forms of seizures, such as amyotonic fits, there are no models. By and large, models of epilepsy are lagging behind models of seizures as most of the former when reproduced in the laboratory are short lived. Spontaneously occurring epilepsies in cats should be studied more widely as they may provide a wide variety of epileptic conditions not dissimilar from the ones seen in humans. Overall, models of seizures and epilepsies are more advanced than the models of most neuropsychiatric conditions.