Leighton J C, Goldstein L J
Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Hematol Oncol Clin North Am. 1995 Apr;9(2):251-73.
Several potential mechanisms of chemotherapy resistance have been identified in adult solid tumors. The multidrug resistance (MDR) phenotype is one mechanism by which tumors may simultaneously develop resistance to multiple chemotherapeutic agents and is associated with P-glycoprotein expression. In this article, the authors examine the literature and summarize the various techniques used to measure MDR1 gene expression, patterns of expression in adult solid tumors.
在成人实体瘤中已确定了几种潜在的化疗耐药机制。多药耐药（MDR）表型是肿瘤可能同时对多种化疗药物产生耐药的一种机制，且与P-糖蛋白表达相关。在本文中，作者查阅了文献并总结了用于测量MDR1基因表达的各种技术以及成人实体瘤中的表达模式。
