The Weldon School of Biomedical Engineering and the Interdisciplinary Biomedical Sciences Program, Purdue University, West Lafayette, Indiana.
Polymer Science and Engineering Department, University of Massachusetts, Amherst, Massachusetts.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Mar;12(2):e1598. doi: 10.1002/wnan.1598. Epub 2019 Dec 2.
The ability to safely and precisely deliver genetic materials to target sites in complex biological environments is vital to the success of gene therapy. Numerous viral and nonviral vectors have been developed and evaluated for their safety and efficacy. This study will feature progress in synthetic polymers as nonviral vectors, which benefit from their chemical versatility, biocompatibility, and ability to carry both therapeutic cargo and targeting moieties. The combination of synthetic gene carrying constructs with advanced delivery techniques promises new therapeutic options for treating and curing genetic disorders. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.
在复杂的生物环境中安全、精确地将遗传物质递送到靶位对于基因治疗的成功至关重要。已经开发和评估了许多病毒和非病毒载体,以评估它们的安全性和有效性。本研究将重点介绍作为非病毒载体的合成聚合物的最新进展,其优势在于其化学多功能性、生物相容性以及携带治疗有效成分和靶向部分的能力。将合成基因载体构建与先进的递药技术相结合,有望为治疗和治愈遗传疾病提供新的治疗选择。本文的特点在于:治疗方法和药物发现 > 肿瘤疾病的纳米医学治疗方法和药物发现 > 新兴技术。