Tarao K, Tamai S, Ito Y, Okawa S, Hayashi M
Department of Medicine, Kanagawa Cancer Center Hospital.
Nihon Shokakibyo Gakkai Zasshi. 1995 Jul;92(7):1037-50.
Lactitol, a non-absorbable synthetic disaccharide, was administered at a dose of 36g/day for 3-4 weeks to 8 patients with liver cirrhosis and hepatic encephalopathy in order to investigate its effects on fecal bacterial flora and clinical symptoms of hepatic encephalopathy. Lactitol significantly increased occupation ratio (ratio to total bacterial number) of anaerobic Bifidobacterium (before administration 7.1% --> after 4 weeks 46.0% (p < 0.05) as well as bacterial count of Lactobacillus. On the other hand, bacterial counts of Bacteroides and Clostridium, which are considered to be NH3-producing bacteria, and that of total aerobic bacteria were not markedly changed, but their occupation ratio were decreased after the administration. Further, tendencies toward decreased fecal pH, increased frequency of defecation and soft stools were observed. As for clinical efficacy, a decrease in blood ammonia concentration, improvement in mental state and flapping tremor were also observed.
乳糖醇是一种不可吸收的合成二糖，以每日36克的剂量给予8例肝硬化合并肝性脑病患者，持续3 - 4周，以研究其对粪便细菌菌群及肝性脑病临床症状的影响。乳糖醇显著增加了厌氧双歧杆菌的占比（占总细菌数的比例）（给药前7.1%，4周后46.0%（p < 0.05））以及乳酸杆菌的细菌计数。另一方面，被认为是产氨细菌的拟杆菌和梭菌的细菌计数以及总需氧菌的细菌计数没有明显变化，但给药后它们的占比下降。此外，还观察到粪便pH值降低、排便频率增加和大便变软的趋势。至于临床疗效，还观察到血氨浓度降低、精神状态改善和扑翼样震颤减轻。
