Tamai K, Majima A, Yan C
Department of Ophthalmology, Nagoya City University Medical School, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Sep;98(9):832-6.
Hypothermic effects on uveal blood flow and postoperative inflammation were evaluated in experimental vitrectomy on albino rabbits. Solutions used for intraocular perfusion were maintained at 9 degrees C and 22 degrees C. Following the vitrectomy, the rabbits' intraocular spaces were irrigated for 60 minutes. The temperature at various sites and the uveal blood flow were measured before and during the procedure. Aqueous protein concentrations were checked on postoperative days 1, 7, and 14. Another solution maintained at 37 degrees C was used as a control. There was a larger decrease in temperature at the retina than there was at the choroid and the ciliary body. Blood flow at the ciliary body decreased to 76.0% and 77.0% at the choroid after 60 minutes of irrigation at 9 degrees C. The decrease at 22 degrees C were 91.0% and 88.3%, respectively. Aqueous protein concentrations at both 9 degrees C and 22 degrees C were significantly lower than at 37 degrees C on the first postoperative day in the eyes irrigated for 60 minutes. In the eyes irrigated for 30 minutes, however, no significant differences were seen. Hypothermia during a prolonged vitrectomy operation seems to decrease inflammation in early postoperative stages.
在白化兔的实验性玻璃体切除术中，评估了低温对葡萄膜血流和术后炎症的影响。用于眼内灌注的溶液保持在9摄氏度和22摄氏度。玻璃体切除术后，对兔眼内空间进行60分钟的冲洗。在手术前和手术过程中测量不同部位的温度和葡萄膜血流。在术后第1天、第7天和第14天检查房水蛋白浓度。另一种保持在37摄氏度的溶液用作对照。视网膜的温度下降幅度大于脉络膜和睫状体。在9摄氏度下冲洗60分钟后，睫状体的血流降至脉络膜的76.0%和77.0%。在22摄氏度下的下降幅度分别为91.0%和88.3%。在术后第一天，冲洗60分钟的眼中，9摄氏度和22摄氏度下的房水蛋白浓度均显著低于37摄氏度下的浓度。然而，在冲洗30分钟的眼中，未观察到显著差异。长时间玻璃体切除术中的低温似乎会降低术后早期的炎症反应。
