Esteve J, Rozman M, Campo E, Muñoz F, Urbano-Ispizua A, Rozman C
Postgraduate School of Hematology Farreras Valenti, University of Barcelona, Hospital Clinic, Spain.
Leukemia. 1995 Aug;9(8):1389-91.
The case of a 44-year-old man diagnosed of a true histiocytic lymphoma who, after autologous bone marrow transplantation, developed leukemia with histiocytic cells is reported. Morphologic, cytochemical, immunophenotypic and genotypic characteristics of malignant cells are described, and the literature about this and related entities is reviewed. In addition, comparison with a recent report of malignant histiocytosis with leukemic involvement is established and its inclusion in the recently proposed subtype of monocytic leukemia with histiocytic differentiation (M5c), suggested.
报告了一例44岁确诊为真性组织细胞淋巴瘤的男性患者，其在自体骨髓移植后发生了伴有组织细胞的白血病。描述了恶性细胞的形态学、细胞化学、免疫表型和基因特征，并复习了关于此及相关实体的文献。此外，与最近一篇关于伴有白血病累及的恶性组织细胞增多症的报告进行了比较，并建议将其纳入最近提出的具有组织细胞分化的单核细胞白血病亚型（M5c）。
