van der Valk P, Meijer C J
Dermatol Clin. 1985 Oct;3(4):705-17.
The classification of histiocytic proliferations in the skin is confusing, largely due to faulty use of terms such as reticulum-cell sarcoma and reticulosis. Immunohistochemical staining procedures and ultrastructural studies have made it possible to differentiate the different cells of the mononuclear phagocyte system. The proliferations discussed here were those of the mononuclear phagocyte system that are associated with characteristic skin manifestations. They include proliferations of monocytes (acute monocytic leukemia), proliferations of tissue macrophages or histiocytes (histiocytic sarcoma and its disseminated form, malignant histiocytosis; familial histiocytoses; and multicentric reticulohistiocytosis), proliferations of Langerhans' cells (histiocytosis X), and proliferations of as yet undefined cells of the mononuclear phagocyte system (sinus histiocytosis with massive lymphadenopathy). Clinical features were presented, and special emphasis was placed on incidence, form, localization, histopathology, and marker profile of the proliferating cells in the skin lesions. The close relationship of the different entities was discussed, as was the importance of immune dysfunction.
皮肤组织细胞增生的分类令人困惑，这主要是由于诸如网状细胞肉瘤和网状细胞增多症等术语的错误使用。免疫组织化学染色程序和超微结构研究使得区分单核吞噬细胞系统的不同细胞成为可能。这里讨论的增生是指与特征性皮肤表现相关的单核吞噬细胞系统的增生。它们包括单核细胞增生（急性单核细胞白血病）、组织巨噬细胞或组织细胞增生（组织细胞肉瘤及其播散形式、恶性组织细胞增生症；家族性组织细胞增多症；以及多中心网状组织细胞增生症）、朗格汉斯细胞增生（组织细胞增生症X），以及单核吞噬细胞系统中尚未明确的细胞增生（伴有巨大淋巴结病的窦性组织细胞增生症）。文中介绍了临床特征，并特别强调了皮肤病变中增生细胞的发病率、形式、定位、组织病理学和标记物特征。讨论了不同实体之间的密切关系，以及免疫功能障碍的重要性。
