Olson S H, Trevisan M, Marshall J R, Graham S, Zielezny M, Vena J E, Hellmann R, Freudenheim J L
Department of Social and Preventive Medicine, State University of New York, Buffalo, NY 14214, USA.
Nutr Cancer. 1995;23(2):141-9. doi: 10.1080/01635589509514370.
Excess weight near the time of diagnosis is a well-established risk factor for endometrial cancer; less is known about the influence of weight at earlier periods of a woman's life or weight gain in adulthood. In a case-control study in western New York State, interviews were conducted with 232 incident endometrial cancer cases, diagnosed between 1986 and 1991, and 631 community controls. Body mass index at 16 years of age and 20, 10, and 2 years before interview and changes in body mass index between these time periods were examined. While being relatively heavy at 16 years of age was associated with slightly increased risk [adjusted odds ratio (OR) = 1.28, 95% confidence interval (CI) = 0.84-1.96], large gains over the entire period from 16 years of age to 2 years ago (OR = 3.45, CI = 2.13-5.57) and high body mass index close to the time of diagnosis (OR = 3.21, CI = 2.01-5.15) were associated with greater risk. Differences in mean body mass index between cases and controls increased over time.
诊断时超重是子宫内膜癌公认的危险因素；而对于女性生命早期体重或成年期体重增加的影响，人们了解较少。在纽约州西部进行的一项病例对照研究中，对1986年至1991年间确诊的232例子宫内膜癌新发病例和631名社区对照进行了访谈。研究人员考察了受访者16岁时、访谈前20年、10年和2年时的体重指数，以及这些时间段内体重指数的变化情况。虽然16岁时相对较重与风险略有增加相关（调整后的优势比[OR]=1.28，95%置信区间[CI]=0.84-1.96），但从16岁到访谈前2年整个期间体重的大幅增加（OR=3.45，CI=2.13-5.57）以及诊断时接近高体重指数（OR=3.21，CI=2.01-5.15）与更高的风险相关。病例组和对照组之间平均体重指数的差异随时间增加。
