Griebel G
Laboratoire de Psychophysiologie, Strasbourg, France.
Pharmacol Ther. 1995 Mar;65(3):319-95. doi: 10.1016/0163-7258(95)98597-j.
An overview of the behavioral data arising from the vast literature concerning the involvement of 5-hydroxytryptamine (5-HT) neurotransmission in the regulation of anxiety is presented. More than 1300 experiments were carried out in this area and they provide evidence that: (1) results obtained in ethologically based animal models of anxiety with drugs stimulating 5-HT transmission are most consistent with the classic 5-HT hypothesis of anxiety in that they show an increase in animals' emotional reactivity; (2) no category of anti-anxiety models are selectively sensitive to the anxiolytic-like effects of drugs targetting 5-HT1A, 5-HT2A or 5-HT2C receptor subtypes; (3) anxiolytic-like effects of 5-HT3 receptor antagonists, in the great part, are revealed by models based on spontaneous behaviors. Taken together, these observations lead to the conclusion that different 5-HT mechanisms, mediated by different receptor subtypes, are involved in the genesis of anxiety.
本文综述了大量有关5-羟色胺（5-HT）神经传递参与焦虑调节的行为学数据。该领域已开展了1300多项实验，这些实验提供了以下证据：（1）在基于行为学的动物焦虑模型中，使用刺激5-HT传递的药物所获得的结果与经典的5-HT焦虑假说最为一致，因为它们显示出动物情绪反应性增加；（2）没有哪一类抗焦虑模型对靶向5-HT1A、5-HT2A或5-HT2C受体亚型的药物的抗焦虑样作用具有选择性敏感性；（3）5-HT3受体拮抗剂的抗焦虑样作用在很大程度上是通过基于自发行为的模型揭示的。综上所述，这些观察结果得出结论：由不同受体亚型介导的不同5-HT机制参与了焦虑的发生。
