Peroutka S J, Sleight A J, McCarthy B G, Pierce P A, Schmidt A W, Hekmatpanah C R
Department of Neurology, Stanford University, CA 94305.
J Neuropsychiatry Clin Neurosci. 1989 Summer;1(3):253-62. doi: 10.1176/jnp.1.3.253.
The past decade has seen important advances in the clinical utility of serotonergic agents. The putative novel anxiolytic effects of 5-HT1A partial agonists such as buspirone, the antidepressant effects of selective serotonin (5-HT) uptake blockers such as fluoxetine, and the unique and potent antiemetic effects of 5-HT3 antagonists in cancer chemotherapy are excellent examples of the clinical relevance of selective 5-HT receptor agents. The increasing ability to modulate serotonergic neurotransmission through distinct 5-HT receptor subtypes should greatly facilitate the analysis of 5-HT in both normal and abnormal human brain function.
过去十年间，血清素能药物的临床应用取得了重要进展。5-羟色胺1A（5-HT1A）部分激动剂（如丁螺环酮）具有假定的新型抗焦虑作用，选择性5-羟色胺（5-HT）摄取阻滞剂（如氟西汀）具有抗抑郁作用，5-HT3拮抗剂在癌症化疗中具有独特且强效的止吐作用，这些都是选择性5-HT受体药物临床相关性的绝佳例证。通过不同的5-HT受体亚型调节血清素能神经传递的能力不断增强，这将极大地促进对正常和异常人类脑功能中5-HT的分析。
