骨质疏松症：定量磁共振成像在诊断中的临床评估

Osteoporosis: clinical assessment with quantitative MR imaging in diagnosis.

作者信息

Wehrli F W, Ford J C, Haddad J G

机构信息

Department of Radiology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.

出版信息

Radiology. 1995 Sep;196(3):631-41. doi: 10.1148/radiology.196.3.7644622.

DOI:10.1148/radiology.196.3.7644622

PMID:7644622

Abstract

PURPOSE

To determine if the magnetic resonance (MR) imaging effective transverse relaxation rate (R2*) of trabecular bone marrow is lowered in osteoporosis.

MATERIALS AND METHODS

R2* was measured in 146 women. Control subjects (n = 77; mean age, 46.6 years) had high mean spinal bone mineral densities (BMDs) and no vertebral deformities. Patients with spinal osteoporosis (n = 59; mean age, 59.7 years) had at least one thoracic vertebral deformity and/or low BMDs.

RESULTS

R2* was lower in patients for L-2 through L-5 (P < .001). Average R2* of L-3 through L-5 (R2av) was the best discriminator (64.79 sec-1 +/- 1.18 [standard error] for control subjects vs 53.39 sec-1 +/- 1.24 for patients; P < .0001). R2av decreased with age in control subjects. The difference in R2av in a subset of 38 age-matched pairs of patients and control subjects was 8.25 sec-1 (P < .0001). Subjects with deformities had lower 52av than did control subjects (52.3 sec-1 +/- 1.6 vs 62.5 sec-1 +/- 1.1, P < .0001). R2*av was correlated with mean BMD (r = .54, P < .0001).

CONCLUSION

Patients with osteoporosis have lower R2*s in vertebral marrow.

摘要

目的

确定骨质疏松症患者小梁骨髓的磁共振成像有效横向弛豫率（R2*）是否降低。

材料与方法

对146名女性进行了R2*测量。对照组（n = 77；平均年龄46.6岁）平均脊柱骨密度（BMD）较高且无椎体畸形。脊柱骨质疏松症患者（n = 59；平均年龄59.7岁）至少有一处胸椎椎体畸形和/或低骨密度。

结果

L-2至L-5节段患者的R2较低（P <.001）。L-3至L-5节段的平均R2（R2av）是最佳鉴别指标（对照组为64.79秒-1±1.18[标准误]，患者组为53.39秒-1±1.24；P <.0001）。对照组中，R2av随年龄增长而降低。在38对年龄匹配的患者和对照组子集中，R2av的差异为8.25秒-1（P <.0001）。有畸形的受试者的52av低于对照组（52.3秒-1±1.6对62.5秒-1±1.1，P <.0001）。R2*av与平均骨密度相关（r =.54，P <.0001）。