Bankier A A, Kiener H P, Wiesmayr M N, Fleischmann D, Kontrus M, Herold C J, Graninger W, Hübsch P
Department of Radiology, University of Vienna, Austria.
Radiology. 1995 Sep;196(3):835-40. doi: 10.1148/radiology.196.3.7644652.
To study the computed tomographic (CT) appearance of early lung involvement in systemic lupus erythematosus (SLE).
In a prospective study, 48 patients with serologically confirmed SLE but no prior clinical evidence of lung involvement underwent chest radiography, CT, and lung function tests. Radiographs and CT scans were compared, and CT scans were evaluated for signs suggestive of parenchymal and pleural disease. Extent and distribution of disease were determined. CT findings were correlated with clinical and functional data.
Of 45 patients with normal chest radiographs, 17 (38%) had abnormal CT findings. Extent of disease was statistically significantly correlated with duration of clinical history (r = .93) and decreased single-breath diffusing capacity for carbon monoxide (r = .8) and ratio of forced expiratory volume in 1 second to forced vital capacity (r = .77).
CT is superior to chest radiography for detection of functionally relevant pulmonary disease and is an important adjunct in early assessment of SLE.
研究系统性红斑狼疮（SLE）早期肺部受累的计算机断层扫描（CT）表现。
在一项前瞻性研究中，48例血清学确诊为SLE但无肺部受累临床证据的患者接受了胸部X线摄影、CT和肺功能检查。对X线片和CT扫描结果进行比较，并对CT扫描结果进行评估，以寻找提示实质和胸膜疾病的征象。确定疾病的范围和分布。将CT表现与临床和功能数据进行关联分析。
45例胸部X线片正常的患者中，17例（38%）CT表现异常。疾病范围与临床病史持续时间（r = 0.93）、一氧化碳单次呼吸弥散量降低（r = 0.8）以及1秒用力呼气容积与用力肺活量之比（r = 0.77）在统计学上显著相关。
CT在检测功能相关的肺部疾病方面优于胸部X线摄影，是SLE早期评估的重要辅助手段。
