Magrini S M, Papi M G, Bagnoli R, Distante V, Bianchi S, Biti G
Dipartimento di Fisiopatologia Clinica, Università di Firenze.
Radiol Med. 1995 Jun;89(6):865-9.
A growing number of children treated for malignant tumors has been cured thanks to progress in the field of pediatric oncology, and therefore long-term treatment sequelae have been more frequently observed. Fourteen of 65 pediatric patients with Wilms' tumor treated in Florence 1957 through 1978, developed lung metastases and six survived at least five years after treatment. Four of these long-term survivors are girls. This paper reports on the long-term sequelae observed in the breast of these four patients: three of them presented breast hypoplasia and one breast cancer. We discuss our personal experience and the relative literature, describing the relationship between given dose and the incidence of breast hypoplasia. Some hypotheses on the etiology of secondary cancer are also discussed.
由于小儿肿瘤学领域的进展，越来越多接受恶性肿瘤治疗的儿童已被治愈，因此长期治疗后遗症也更频繁地被观察到。1957年至1978年在佛罗伦萨接受治疗的65例威尔姆斯瘤小儿患者中，有14例发生了肺转移，6例在治疗后存活至少5年。这6名长期幸存者中有4名是女孩。本文报告了在这4名患者乳房中观察到的长期后遗症：其中3例出现乳腺发育不全，1例患乳腺癌。我们讨论了我们的个人经验和相关文献，描述了给定剂量与乳腺发育不全发生率之间的关系。还讨论了一些关于继发性癌症病因的假设。
