Egeler R M, Wolff J E, Anderson R A, Coppes M J
Southern Alberta Children's Cancer Program, Alberta Children's Hospital and Tom Baker Cancer Centre, Calgary, Canada.
Semin Urol Oncol. 1999 Feb;17(1):55-61.
An increasing number of children with Wilms' tumor can expect to be cured, reflecting the undisputed progress made in the treatment of children with this renal cancer. However, it does underscore the need to screen survivors for late effects of cancer therapy. Some of the late effects, such as those following radiation therapy, should be expected after a considerable latent period. Others, such as those occurring after the administration of certain chemotherapeutics agents, are commonly immediate, usually transient, but occasionally permanent. Although children seem to tolerate acute toxicities of therapy better than do adults, the growing child may be more vulnerable to the delayed adverse sequelae of cancer therapy, such as effects on growth, fertility, and neuropsychological function. This article reviews many of the late effects seen in survivors of Wilms' tumor and the way in which these effects relate to the different therapeutical modalities used (surgery, chemotherapy, and radiation).
越来越多的威尔姆斯瘤患儿有望治愈，这反映出在这种肾癌患儿的治疗方面取得了无可争议的进展。然而，这确实凸显了对幸存者进行癌症治疗晚期效应筛查的必要性。有些晚期效应，比如放疗后的效应，会在相当长的潜伏期后出现。其他一些效应，比如使用某些化疗药物后出现的效应，通常是即刻发生的，一般是短暂的，但偶尔也会是永久性的。虽然儿童似乎比成人更能耐受治疗的急性毒性，但成长中的儿童可能更容易受到癌症治疗延迟性不良后果的影响，比如对生长、生育能力和神经心理功能的影响。本文综述了威尔姆斯瘤幸存者中出现的许多晚期效应，以及这些效应与所采用的不同治疗方式（手术、化疗和放疗）之间的关系。
