紫杉醇抑制间皮瘤异种移植物的生长。
Taxol inhibits growth of mesothelioma xenografts.
作者信息
Lee J M, Bruckner H W, Szrajer L, Brenne U, Schindelheim G, Andreotti P E
机构信息
Derald H. Ruttenberg Cancer Center, Mount Sinai Medical Center, New York, NY 10029, USA.
出版信息
Anticancer Res. 1995 May-Jun;15(3):693-6.
BACKGROUND
In vitro tests measuring inhibition of adenosine triphosphate activity predicted three mesothelioma xenografts would be sensitive to taxol.
PURPOSE
The in vivo therapeutic efficacy of taxol was tested in nude mice carrying the subcutaneous tumors.
METHODS
Once tumor growth reached 100mm3 in size, intraperitoneal taxol, 30 mg/kg, on a day 1, 4, and 8 schedule, was administered to mice bearing subcutaneous mesothelioma xenografts.
RESULTS
Taxol inhibits the growth of all three cell lines. It produces actual tumor regression including some complete responses.
CONCLUSIONS
Taxol is an active drug against mesothelioma. The in vitro cell lines and the in vivo system are useful tools for screening and developing new treatments for mesothelioma.
背景
测量三磷酸腺苷活性抑制的体外试验预测三种间皮瘤异种移植物对紫杉醇敏感。
目的
在携带皮下肿瘤的裸鼠中测试紫杉醇的体内治疗效果。
方法
一旦肿瘤生长到100立方毫米大小，对携带皮下间皮瘤异种移植物的小鼠按照第1、4和8天的日程安排腹腔注射30毫克/千克的紫杉醇。
结果
紫杉醇抑制所有三种细胞系的生长。它能使肿瘤实际消退，包括一些完全缓解的情况。
结论
紫杉醇是一种抗间皮瘤的活性药物。体外细胞系和体内系统是筛选和开发间皮瘤新治疗方法的有用工具。
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