Abou-Issa H, Moeschberger M, el-Masry W, Tejwani S, Curley R W, Webb T E
Department of Surgery, College of Medicine, Ohio State University, Columbus 43210, USA.
Anticancer Res. 1995 May-Jun;15(3):805-10.
The independent effects of the potential cancer chemopreventive agent calcium glucarate (CGT) when fed (128 mmol/kg diet) during the initiation (I), promotion (P) or (I+P) phases of 7,12-dimethylbenzanthracene-induced rat mammary carcinogenesis, was compared to that of the known chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) fed (2.0 mmol/kg diet) during these same phases. CGT and especially 4-HPR both significantly increased tumor latency when fed during the P-phase. When fed during I, P or I+P phases mammary tumor incidence was reduced compared to the controls 33%, 42% and 67% by 4-HPR and 18%, 42% and 50% by CGT. Similarly, tumor multiplicity was significantly reduced by either agent. For example, as compared to the corresponding control, when fed during the I, P or I+P phases 4-HPR reduced tumor multiplicity 63, 34 and 63%, while CGT reduced tumor multiplicity 28, 42 and 63% respectively. CGT, like 4-HPR, acts on both the I and P phases with the effect being maximal when fed during P and I+P phases.
在7,12-二甲基苯并蒽诱导的大鼠乳腺癌发生的起始期（I）、促进期（P）或（I+P）阶段，将潜在的癌症化学预防剂葡萄糖醛酸钙（CGT，以128 mmol/kg饮食喂养）的独立作用，与在相同阶段喂养的已知化学预防剂N-(4-羟基苯基)视黄酰胺（4-HPR，以2.0 mmol/kg饮食喂养）的作用进行了比较。当在促进期（P）喂养时，CGT尤其是4-HPR均显著延长了肿瘤潜伏期。在起始期（I）、促进期（P）或（I+P）阶段喂养时，与对照组相比，4-HPR使乳腺肿瘤发生率分别降低了33%、42%和67%，CGT使其分别降低了18%、42%和50%。同样，两种药物均显著降低了肿瘤多发性。例如，与相应对照组相比，在起始期（I）、促进期（P）或（I+P）阶段喂养时，4-HPR使肿瘤多发性分别降低了63%、34%和63%，而CGT分别降低了28%、42%和63%。CGT与4-HPR一样，对起始期（I）和促进期（P）均有作用，在促进期（P）和（I+P）阶段喂养时效果最佳。
