Waeber B, Weber R, Brunner H R
Division d'hypertension, Centre hospitalier universitaire vaudois, Lausanne, Suisse.
Arch Mal Coeur Vaiss. 1995 Feb;88 Spec No 2:9-14.
Left ventricular hypertrophy (LVH) is an early complication of hypertension. To a certain degree, this process counteracts the parietal stress induced by high blood pressure. Genetic factors, obesity, high salt diet and different growth factors, notably angiotensin II and noradrenaline, can also predispose to hypertrophic cardiomyopathy. Left ventricular mass is increased on echocardiography in about 20% of hypertensive subjects. LVH is initially associated with a change in myocardial diastolic function and later with abnormal systolic function. It is a major risk factor, a cause of cardiac failure, reduction in coronary reserve and of ventricular arrhythmias. Treatment of hypertension is associated with regression of LVH and preservation or improvement in myocardial diastolic and systolic functions. The decrease in left ventricular mass could reduce the incidence of cardiovascular complications in hypertension.
左心室肥厚（LVH）是高血压的早期并发症。在一定程度上，这一过程可抵消高血压引起的壁应力。遗传因素、肥胖、高盐饮食以及不同的生长因子，尤其是血管紧张素II和去甲肾上腺素，也可诱发肥厚型心肌病。约20%的高血压患者经超声心动图检查显示左心室质量增加。LVH最初与心肌舒张功能改变有关，随后与收缩功能异常有关。它是主要的危险因素，是心力衰竭、冠状动脉储备减少和室性心律失常的病因。高血压治疗与LVH消退以及心肌舒张和收缩功能的保留或改善相关。左心室质量的降低可减少高血压患者心血管并发症的发生率。
