一种新型蛋白质，即淀粉样前体样蛋白2，存在于人类大脑、脑脊液和条件培养基中。
A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media.
作者信息
Webster M T, Groome N, Francis P T, Pearce B R, Sherriff F E, Thinakaran G, Felsenstein K M, Wasco W, Tanzi R E, Bowen D M
机构信息
Miriam Marks Department of Neurochemistry, Institute of Neurology, London, U.K.
出版信息
Biochem J. 1995 Aug 15;310 ( Pt 1)(Pt 1):95-9. doi: 10.1042/bj3100095.
A monoclonal antibody, 3B11, was raised to a novel protein, amyloid precursor-like protein 2, which did not recognize amyloid precursor protein. Multiple bands were detected in human brain fractions and cell lysate by Western blotting, indicating the presence of isoforms, 3B11 immunoreactivity was also detected in cerebrospinal fluid and conditioned medium, indicating that the protein is secreted. Immunocytochemistry revealed 3B11 immunoreactivity in sections of human brain.
一种单克隆抗体3B11是针对一种新型蛋白质——淀粉样前体样蛋白2产生的，它不识别淀粉样前体蛋白。通过蛋白质印迹法在人脑部分和细胞裂解物中检测到多条带，表明存在同工型，在脑脊液和条件培养基中也检测到3B11免疫反应性，表明该蛋白是分泌型的。免疫细胞化学显示在人脑切片中有3B11免疫反应性。
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