尸检大脑显示，与其他痴呆症相比，阿尔茨海默病患者的淀粉样前体蛋白样免疫反应相似但不完全相同。
Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias.
作者信息
Webster M T, Francis P T, Procter A W, Stratmann G C, Doshi R, Mann D M, Bowen D M
机构信息
Department of Neurochemistry, Institute of Neurology, London, UK.
出版信息
Brain Res. 1994 May 2;644(2):347-51. doi: 10.1016/0006-8993(94)91702-7.
Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and other dementias. There were no significant differences between AD and other cases in species with the Kunitz protease inhibitor domain. However, the total soluble APPLIR was higher in AD and it was hypothesized that this relates to cholinergic hypoactivity.
已通过蛋白质免疫印迹法测定了阿尔茨海默病（AD）和其他痴呆症患者大脑皮质两个区域的可溶性部分和两个膜部分中淀粉样前体蛋白（APP）样免疫反应性（APPLIR）的浓度。在具有库尼茨蛋白酶抑制剂结构域的物种中，AD与其他病例之间没有显著差异。然而，AD患者的总可溶性APPLIR较高，据推测这与胆碱能功能减退有关。
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