Sugumaran M, Bolton J
Department of Biology, University of Massachusetts at Boston 02125, USA.
Biochem Biophys Res Commun. 1995 Aug 15;213(2):469-74. doi: 10.1006/bbrc.1995.2155.
The hapatotoxicity of safrole and related compounds has been attributed to the electrophilic compounds generated from the oxidation of these chemicals. In this paper, for the first time using quasi pre-steady state conditions, we present direct evidence for the rapid production of electrophilic allyl o-quinone and its tautomerization to more stable and reactive vinyl p-quinone methide during both the enzyme catalyzed and chemical mediated oxidation of 4-allylcatechol, an in vivo product of safrole metabolism.
黄樟素及相关化合物的肝毒性归因于这些化学物质氧化产生的亲电化合物。在本文中，我们首次在准预稳态条件下，给出了亲电烯丙基邻醌快速生成及其在酶催化和化学介导的4-烯丙基儿茶酚（黄樟素代谢的体内产物）氧化过程中向更稳定且反应性更强的乙烯基对醌甲基化物互变异构的直接证据。
