Osman M Y, Abdel Tawab S M, Sharaf I A
Biochemistry Department, Alexandria University, Egypt.
Arzneimittelforschung. 1995 Jun;45(6):663-5.
Inhibition of acetylcholinesterase (AChE) in the whole brain, cerebellum, pons, frontal cortex, basal ganglia and medulla oblongata of rat brain by physostigmine (CAS 57-47-6) in vitro was studied. Constants characterizing this inhibition namely: binding constant (KI) and bimolecular rate constant (K'2) were determined. The highest values of K'2 were obtained in the cases of pons and medulla oblongata, the parts responsible for the respiratory and vital centers. The difference in the inhibition of AChE in the different parts of the brain could be due to the difference in the grey and white matters contents in these parts.
研究了毒扁豆碱（CAS 57-47-6）在体外对大鼠全脑、小脑、脑桥、额叶皮质、基底神经节和延髓中乙酰胆碱酯酶（AChE）的抑制作用。测定了表征这种抑制作用的常数，即结合常数（KI）和双分子速率常数（K'2）。在脑桥和延髓（负责呼吸和生命中枢的部分）的情况下获得了最高的K'2值。大脑不同部位AChE抑制作用的差异可能是由于这些部位灰质和白质含量的差异。
