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What is the true clinical significance of plasma protein binding displacement interactions?

作者信息

Sansom L N, Evans A M

机构信息

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide.

出版信息

Drug Saf. 1995 Apr;12(4):227-33. doi: 10.2165/00002018-199512040-00001.

DOI:10.2165/00002018-199512040-00001
PMID:7646820
Abstract
摘要

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1
What is the true clinical significance of plasma protein binding displacement interactions?
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4
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5
[Drug plasma protein binding and pharmacokinetics].[药物血浆蛋白结合与药代动力学]
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Vrach Delo. 1991 Nov(11):35-41.
8
Dose-dependent pharmacokinetics.
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9
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Adv Biol Skin. 1972;12:51-60.
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Drug Interactions: A Source Book of Adverse Interactions, Their Mechanisms, Clinical Importance and Management.《药物相互作用：不良相互作用、作用机制、临床重要性及处理方法资料手册》
Ann Intern Med. 2000 Nov 7;133(9):760. doi: 10.7326/0003-4819-133-9-200011070-00041.
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Plasma protein binding and pharmacological response.血浆蛋白结合与药理反应。
Clin Pharmacokinet. 1993 Jun;24(6):435-40. doi: 10.2165/00003088-199324060-00001.
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Plasma protein binding displacement interactions--why are they still regarded as clinically important?
Pharmacokinetic Profile of Doxycycline in Koala Plasma after Weekly Subcutaneous Injections for the Treatment of Chlamydiosis.
每周皮下注射强力霉素治疗考拉衣原体病后，强力霉素在考拉血浆中的药代动力学特征。
Animals (Basel). 2022 Jan 20;12(3):250. doi: 10.3390/ani12030250.
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Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats.测定和确定体外盐酸甲氟喹与临床正常和猫传染性腹膜炎（FIP）患猫血浆蛋白的结合情况。
PLoS One. 2020 Aug 5;15(8):e0236754. doi: 10.1371/journal.pone.0236754. eCollection 2020.
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Clinical pharmacology of deferasirox.地拉罗司的临床药理学
Clin Pharmacokinet. 2014 Aug;53(8):679-94. doi: 10.1007/s40262-014-0151-4.
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The clinical relevance of plasma protein binding changes.血浆蛋白结合变化的临床相关性。
Clin Pharmacokinet. 2013 Jan;52(1):1-8. doi: 10.1007/s40262-012-0018-5.
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Clinically significant psychotropic drug-drug interactions in the primary care setting.初级保健环境中的具有临床意义的精神药物药物相互作用。
Curr Psychiatry Rep. 2012 Aug;14(4):376-90. doi: 10.1007/s11920-012-0284-9.
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Stress can affect drug pharmacokinetics via serum/tissues protein binding and blood flow rate alterations.压力可通过血清/组织蛋白结合及血流速率改变来影响药物的药代动力学。
Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):1-7. doi: 10.1007/s13318-011-0077-2. Epub 2011 Dec 16.
9
The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery.血浆蛋白结合对体内疗效的影响：药物发现中的误解。
Nat Rev Drug Discov. 2010 Dec;9(12):929-39. doi: 10.1038/nrd3287.
10
The role of the protein-binding on the mode of drug action as well the interactions with other drugs.蛋白质结合在药物作用模式以及与其他药物相互作用方面的作用。
Eur J Drug Metab Pharmacokinet. 2008 Oct-Dec;33(4):225-30. doi: 10.1007/BF03190876.
血浆蛋白结合置换相互作用——为何它们仍被视为具有临床重要性？
Br J Clin Pharmacol. 1994 Feb;37(2):125-8. doi: 10.1111/j.1365-2125.1994.tb04251.x.
4
Clinically significant drug interactions with the oral anticoagulants.与口服抗凝剂具有临床意义的药物相互作用。
Drug Saf. 1994 May;10(5):381-94. doi: 10.2165/00002018-199410050-00003.
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Drug interactions with fibric acids.
Pharmacol Ther. 1994 Aug;63(2):163-76. doi: 10.1016/0163-7258(94)90043-4.
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Interaction between diflunisal and warfarin.双氟尼酸与华法林之间的相互作用。
Clin Pharmacol Ther. 1980 Oct;28(4):493-8. doi: 10.1038/clpt.1980.193.
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Stereoselective interaction of phenylbutazone with [12C/13C]warfarin pseudoracemates in man.苯基布他松与人[12C/13C]华法林假外消旋体的立体选择性相互作用。
J Clin Invest. 1980 Mar;65(3):746-53. doi: 10.1172/JCI109722.
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Kinetics of drug displacement interactions.药物置换相互作用的动力学
J Pharmacokinet Biopharm. 1981 Apr;9(2):181-90. doi: 10.1007/BF01068081.
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Effect of single doses of sodium valproate on serum phenytoin levels and protein binding in epileptic patients.
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Potentiation of warfarin-induced hypoprothrombinemia by chloral hydrate.
N Engl J Med. 1970 Oct 15;283(16):827-31. doi: 10.1056/NEJM197010152831601.