Aarons L J, Rowland M
J Pharmacokinet Biopharm. 1981 Apr;9(2):181-90. doi: 10.1007/BF01068081.
A simple model simulating the kinetics of drugs displacement kinetics is investigated. It is demonstrated that for highly bound, lowly cleared drugs, displacement interactions are transitory. Consequently, the kinetics of the interaction have to be considered as well as the in vitro interaction. It is possible to have a significant in vitro displacement interaction with no in vivo counterpart. Methods of moderating drug displacement by adjusting the rate and the timing of administration of the displacing agent are discussed.
研究了一个模拟药物置换动力学的简单模型。结果表明，对于高结合率、低清除率的药物，置换相互作用是短暂的。因此，必须考虑相互作用的动力学以及体外相互作用。有可能在体外有显著的置换相互作用，但在体内却没有相应的情况。讨论了通过调整置换剂给药速率和时间来调节药物置换的方法。
