Teixeira F, Alonso E, Romero V, Ortíz A, Martínez C, Otero E
Department of Experimental Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
J Psychiatry Neurosci. 1995 Jul;20(4):276-82.
The object of this study is to investigate whether or not there are clinical signs and symptoms in patients with dementia that, by themselves or jointly, can be associated with the pathological diagnosis of Alzheimer's disease. Twelve patients with dementia were studied, in whom the clinical diagnosis of Alzheimer's disease was made according to established criteria. A sample of leptomeninges, cortex and subcortical white matter was obtained from each patient and was processed for light and electron microscopy. In the cases in whom neuritic plaques and neurofibrilary tangles were present, pathological changes were quantified. The diagnosis of Alzheimer's disease was confirmed in 5 cases, whereas in 3 patients spongiform encephalopathy was present. In the remaining patients, the number of neuritic plaques was within normal limits for the age of the subjects. Comparison of the data in Alzheimer (n = 5) and non-Alzheimer (n = 7) groups showed an increased, statistically significant incidence of acalculia, abnormalities of judgment, impairment of abstraction and primitive reflexes in the former. Although good fitting models were obtained, none achieved perfect discrimination. The model that included alterations of judgment and acalculia gave the best fit.
本研究的目的是调查痴呆患者是否存在单独或共同与阿尔茨海默病病理诊断相关的临床体征和症状。对12例痴呆患者进行了研究，这些患者根据既定标准被临床诊断为阿尔茨海默病。从每位患者身上获取软脑膜、皮质和皮质下白质样本，并进行光镜和电镜检查。在存在神经炎性斑块和神经原纤维缠结的病例中，对病理变化进行了量化。5例确诊为阿尔茨海默病，3例存在海绵状脑病。其余患者的神经炎性斑块数量在受试者年龄的正常范围内。阿尔茨海默病组（n = 5）和非阿尔茨海默病组（n = 7）的数据比较显示，前者失算症、判断力异常、抽象能力受损和原始反射的发生率增加，具有统计学意义。尽管获得了拟合良好的模型，但没有一个模型能实现完美区分。包含判断力改变和失算症的模型拟合效果最佳。
