Heston L L, Mastri A R, Anderson V E, White J
Arch Gen Psychiatry. 1981 Oct;38(10):1085-90. doi: 10.1001/archpsyc.1981.01780350019001.
Relatives of 125 probands, who had dementia of the Alzheimer type as proved by autopsy, were subjects of a genetic investigation. The relatives exhibited an excess of dementing illness consistent with genetic transmission. Risk to relatives decreased sharply as severity of the proband's illness decreased. Also, when compared with a control group and the general population, the relatives had excesses of Down's syndrome, lymphoma, and immune diatheses. These associated conditions also were more likely to be present when the proband had severe illness. Mortality at all ages was increased among the relatives.
125名经尸检证实患有阿尔茨海默型痴呆症的先证者的亲属成为了一项基因研究的对象。这些亲属中痴呆症的发病率高于正常水平，提示存在遗传传递现象。随着先证者病情严重程度的降低，其亲属患病风险急剧下降。此外，与对照组和普通人群相比，这些亲属中唐氏综合征、淋巴瘤和免疫素质的发病率更高。当先证者病情严重时，这些相关病症也更有可能出现。各年龄段亲属的死亡率均有所上升。
